The NeoTYPE ALL Profile is intended as an aid in diagnostic subtyping, risk assessment, and therapy selection of acute lymphoblastic leukemia (ALL) with a focus on Ph+ and Ph-like B-ALL subtypes. It is appropriate for both adult and pediatric ALL patients. Sequencing DNA and RNA via NGS, NeoTYPE ALL Profile detects SNVs/InDels in 21 genes, copy number variations in 3 tumor-suppressor genes (CDKN2A, IKZF1, and TP53), fusions in 30 genes, and gene overexpression in 2 genes (CRLF2 and EPOR). FISH components are also included to detect IGH::CRLF2 and IGH::EPOR fusions.