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MYRIADE



Videodrop : Measuring Size & Concentration of Viruses

Myriade develops the VIDEODROP, an innovative nanoscale imaging technology. Videodrop makes possible to measure in a single drop the size and concentration of living nanoparticles between 70nm and 10 microns without labeling in real time. Thanks to the Videodrop, you can continuously monitor viral vector solutions of Lentiviruses & adenoviruses.

Brands: VIDEODROP


 Videos

Videodrop: Measuring Size & Concentration of virus
Videodrop : The Applications
Videodrop : How to do measure in 40s

 Products

  • VIDEODROP
    Videodrop makes it possible to measure the size & concentration of lentivirus and adenovirus in the range of 70 nm and 10 microns without labeling, in real time in a single drop without purification in complex & viscous samples
    ...

  • The Context

    Gene and Cell therapies (GCT) are booming. Thanks to viral vectors, genetic material is introduced into the patient's deficient cells to modify the genetic defect or manage the disease.Ensuring the efficacy and safety of these new drugs is key.

    Virus concentration & purity of the solution must be precisely determined. However, viruses are invisible with standard optical techniques.

    Today, due to the lack of solutions allowing continuous controls all along the biomanufacturing chain, the manufacturers work almost blindly (limited control point) for 4 weeks & a cost of 500.000€ per treatment.

    Therefore, there is a major need for an "in-process" quality control method for viral vector batches for the industrial development of GCTs.


    The Product

    Myriade, (www.myriadelab.com) develops an innovative nanoscale imaging technology: VIDEODROP.

    Based on the principles of interferometry, VIDEODROP makes it possible to measure Size & Concentration of lentivirus & adenvirus
    • in the range of 30 nm and 10 microns
    • in real time (40s)
    • in a single drop (5µL)
    • without labelling
    • without purification if required
    • on viscous & complex samples

    VIDEODROP is as a new tool for bioproduction follow-up :
    • At early stage of development, Videodrop can be used for :
      • Yield calculation,
      • Process optimization 
      • Formulation screening
    • At a late stage of development, Videodrop can be positionned for in-process controls and final product characterization


    Videodrop is the ideal "at-line" system for fast "in-process" controls of complex solutions containing viruses & extracellular vesicles


    Contact: Philippe Garabedian, COO, philippe.garabedian@myriadelab.com