Unchained Labs

Pleasanton,  CA 
United States
https://www.unchainedlabs.com/

Here’s the deal. We’re all about helping researchers break free from tools that just don’t cut it. Unleashing problem-tackling products that make a huge difference in the real science they do every day. Check out our epic gene therapy tools!
  

Uncle - stability screener 
Big Tuna - buffer exchanger  
Stunner
 - gene therapy savior

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 Products

  • Epic Gene Therapy Tools
    Get hassle-free AAV & LNP sample prep and characterization from Unchained Labs’ gene therapy squad...

  • Getting almost anything done on AAVs and LNPs takes too much sample and time – which is why we developed the Gene Therapy Squad. Stunner delivers easy and efficient answers for AAV with empty/full ratio and total capsid titer using only 2 µL of sample. For lipid nanoparticles (LNPs) Stunner delivers DLS data while pinpointing total RNA quantification at the same time. 
     
    When it’s time to test out the stability of your capsids, Uncle gives new insight on AAV stability by monitoring DNA ejection from capsids, in addition to protein unfolding and aggregation. Uncle shows which capsids and conditions are the most stable both degradation routes for different serotypes and buffer conditions.
     
    Researchers developing AAVs or LNPs need a better option for sample clean up, concentration, and buffer exchange – and Big Tuna can now tackle all three chores with high-throughput automation. Big Tuna off-loads sample prep for AAVs, LNP, and nucleic acid samples fast and consistently without compromising sample integrity or recovery.
     
    Learn how all these tools deliver unique insights and faster results on AAV and LNP samples to solve your next problem faster.