SAN High Quality® is the ultimate solution for efficient removal of nucleic acids in high-salt manufacturing and bioprocessing workflows. This non-specific endonuclease has optimum activity at salt concentrations between 400 – 600 mM, allowing significant improvements in efficiency and yield. SAN High Quality is also used to eliminate exogenous DNA contamination for in-process qPCR titer measurements. Following the efficient contamination clearance, the nuclease can easily be inactivated at PCR-friendly conditions. Viral DNA is protected by capsids, and remains intact also after the viral lysis.
M-SAN High Quality® is a novel, nonspecific endonuclease with excellent performance at physiological conditions found in typical cell media. M-SAN HQ outperforms other commercially available nucleases in removal of DNA impurities at conditions often used for manufacture of fragile viral vectors such as lentiviruses.