Botox Effect Active Serum's innovative formula combines botanical science, neuroscience, and glycobiology to help skin look smoother, firmer, and more youthful. Professional grade natural ingredients CALMOSENSINE™, GLYCOLIFT®, and vitamins prevent the onset of new wrinkles caused by repeated facial expressions and diminish visible signs of aging. CALMOSENSINE™ consists of two amino acids - tyrosine and arginine, protein building blocks naturally found in the human body. CALMOSENSINE™ is the first cosmetic active that acts as a messenger for the senses. It modulates the perception of unpleasant sensations and helps put the skin at ease, creating a more comfortable and relaxed sensation. GLYCOLIFT™ biosaccharide substance imparts a "second skin" effect for protection from external factors, deeply moisturizes, instantly tightens, and smoothes skin.